• essenbio
• 11 Oct, 2017

CD47 is a cell surface ‘don’t eat me’ signal that has been shown to be important in detection and evasion of cancer cells, inflammation, neuronal pruning and other pathophysiological processes. Healthy cells express CD47 to avoid attack by phagocytes, or in the case of neurons, the level of CD47 expression can modulate the ‘pruning’ of injured cells by microglia. CD47 is commonly overexpressed in tumor cells and prevents their engulfment, resulting in unchecked tumor growth.
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