Amorphous Formulations for Bioavailability Enhancement: Risks and Opportunities

Solubility is a major challenge in the development of oral solid dosage forms. Amorphous formulation with polymeric solid dispersions have been the technology of choice to enhance solubility. However, this approach may have some downfalls when considering the ability to successfully stabilize compounds, especially poor glass former compounds with high propensity to re-crystallize.
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